An experimental skin cancer vaccine significantly reduced the risk of melanoma returning or spreading in a late-stage clinical trial from Merck and Moderna. The results mark the first positive Phase 3 trial of an mRNA-based personalized cancer therapy , according to the companies. Known as INTerpath-001, the study evaluated 1,137 patients globally who had surgery to remove high-risk (Stage IIB through Stage IV) melanoma. Patients were randomly assigned to receive either Keytruda, plus the personalized vaccine, or Keytruda, plus placebo. 'TANMAXXING' TREND COULD COME AT A DANGEROUS COST, SKIN CANCER EXPERTS WARN Patients who received the combination experienced significantly better "recurrence-free survival," meaning their cancer was less likely to return than in those who received Keytruda alone. The combination also significantly improved "distant metastasis-free survival," a measure of how long patients remained alive without the cancer spreading to dist...
Frank Isola comments on Michael Wilbon naming him preferred 'PTI' co-host when Tony Kornheiser retires
ESPN's "Pardon the Interruption" is the highest-rated sports program on television, a distinction it has held for much of its near 25-year run. The show's simple format remains largely the same, as do its two co-hosts. ESPN has had little reason to tweak the format or cast. That is unlikely to change while Tony Kornheiser and Michael Wilbon remain. Sources tell OutKick that the co-hosts signed new three-year deals earlier this year, with the expectation that both will fulfill their contracts. Still, both have made more than enough money to walk away at any time of their own accord. Kornheiser is 78 years old. Wilbon turns 68 in November. Wilbon, who is 10 years younger than Kornheiser, was asked by Awful Announcing this week whether he has pondered hosting the show if Kornheiser retires before him. "We do, because we do," Wilbon said when asked if he's considered continuing the show without his long-time partners. "With substitutes all along the wh...