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Cancer vaccine prevents deadly melanoma from returning or spreading in landmark trial

An experimental skin cancer vaccine significantly reduced the risk of melanoma returning or spreading in a late-stage clinical trial from Merck and Moderna. The results mark the first positive Phase 3 trial of an mRNA-based personalized cancer therapy , according to the companies. Known as INTerpath-001, the study evaluated 1,137 patients globally who had surgery to remove high-risk (Stage IIB through Stage IV) melanoma. Patients were randomly assigned to receive either Keytruda, plus the personalized vaccine, or Keytruda, plus placebo. 'TANMAXXING' TREND COULD COME AT A DANGEROUS COST, SKIN CANCER EXPERTS WARN Patients who received the combination experienced significantly better "recurrence-free survival," meaning their cancer was less likely to return than in those who received Keytruda alone. The combination also significantly improved "distant metastasis-free survival," a measure of how long patients remained alive without the cancer spreading to dist...
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Frank Isola comments on Michael Wilbon naming him preferred 'PTI' co-host when Tony Kornheiser retires

ESPN's "Pardon the Interruption" is the highest-rated sports program on television, a distinction it has held for much of its near 25-year run. The show's simple format remains largely the same, as do its two co-hosts. ESPN has had little reason to tweak the format or cast. That is unlikely to change while Tony Kornheiser and Michael Wilbon remain. Sources tell OutKick that the co-hosts signed new three-year deals earlier this year, with the expectation that both will fulfill their contracts. Still, both have made more than enough money to walk away at any time of their own accord. Kornheiser is 78 years old. Wilbon turns 68 in November. Wilbon, who is 10 years younger than Kornheiser, was asked by Awful Announcing this week whether he has pondered hosting the show if Kornheiser retires before him. "We do, because we do," Wilbon said when asked if he's considered continuing the show without his long-time partners. "With substitutes all along the wh...

Sean Duffy faces family dilemma over embattled Ivy League school and Christian values

Transportation Secretary Sean Duffy accused Harvard University of indoctrinating students with ideas that run counter to his Christian values, raising concerns about whether his own daughter should attend the prestigious Ivy League school. "I don't want them to get one viewpoint," Duffy said on an episode of the Department of Transportation-sponsored YouTube series "The Great American Roadtrip." "I want them to get a lot of different viewpoints, but I don't want them fed only one viewpoint that's contrary to the way my kids were raised." The comments come as Duffy's daughter, Paloma, expressed interest in attending Harvard University, saying she couldn't turn down the opportunity if accepted. CONSERVATIVE RADIO HOST CALLS OUT ANA NAVARRO'S CLAIM ABOUT SEAN DUFFY'S ROAD TRIP IN HEATED CLASH "But mom and I can," Duffy said, referring to his wife, Rachel Campos-Duffy, a Fox News host. The couple has been married since 199...

Disney alum Christy Carlson Romano rips Hollywood for failing child stars after Hayden Panettiere’s death

For years, Christy Carlson Romano has used her platform to expose the pitfalls of Hollywood. Now, in the wake of Hayden Panettiere’s death , the former child star is calling for stronger safeguards to protect young actors from the lasting consequences of growing up in the spotlight. In a new op-ed for Elle , the Disney alum — who starred on "Even Stevens" from 2000 to 2003 as a young teen — compared early fame to CTE (chronic traumatic encephalopathy) while ripping Hollywood executives, networks and stage parents for failing to do more to protect young performers during their most formative years. "The former child actor exists in a category the world does not know how to hold," she wrote. "We are children when the public wants to feel protective of us, professionals when the industry wants to profit from us, and spoiled celebrities when we eventually show symptoms of having been both." BELLA THORNE SAYS HOLLYWOOD TREATED HER LIKE A KID ON SCREEN AND AN A...

Prosecutor corners Lindsay Clancy's Catholic mother-in-law with 'mortal sin' question

Prosecutors played the faith card Tuesday, asking Lindsay Clancy's Catholic mother-in-law if she knew murder is a mortal sin. It was part of their push to show Clancy knew what she was doing when she killed her three children, not that she was in postpartum psychosis as the defense claims. Lindsay Clancy, 36, is charged with three counts of first-degree murder in the deaths of her three children — Cora, Dawson and Callan, all under 6 years old, who were found strangled in the family's Duxbury home in 2023. Prosecutors concluded their case Monday morning. On Tuesday, Assistant District Attorney Shanan Buckingham asked Susan Clancy, Lindsay's mother-in-law and a Catholic, if she knew murder was a "mortal sin." POSTPARTUM MOM LINDSAY CLANCY ON TRIAL FOR MURDER BRINGS COURT TO A HALT WITH SUDDEN BREAKDOWN Susan Clancy didn't answer the question, and Judge William Sullivan immediately called a sidebar and struck the remark from the record. SEND US A TIP Susan Cla...

Charlamagne blasts 'dumb' Democrats for getting drawn into WNBA transgender debate ahead of midterms

Charlamagne tha God slammed the debate over transgender participation in women's sports, particularly the WNBA , during his "Brilliant Idiots" podcast on Sunday, saying the conversation was "ridiculous." "I think this s--- is ridiculous," Charlamagne said . "I don't know why this is becoming a story again, and I cannot believe that people are falling for tricks like this right before the midterm elections. This is so dumb for Democrats to even be going back down this road having this conversation." The discussion came in the wake of WNBA star Sophie Cunningham, who plays for the Indiana Fever, taking a stand against transgender participation in women's sports. Other WNBA players have said they hold the opposite views, as well as coaches, including Minnesota Lynx coach Cheryl Reeve, who recently wore a "Trans Kids Belong" T-shirt to the team's game against the Fever. "And I hate when they conflate two things,"...

Long Island street takeover erupts as drivers block road, perform donuts, burnouts: police

Fifteen people were arrested, and seven vehicles were impounded after police descended on an alleged street takeover that brought reckless driving, burnouts and donuts to a Long Island roadway early Saturday, authorities said. The Suffolk County Police Department said its Street Takeover Task Force got wind of the planned gathering through intelligence gathering and social media monitoring ahead of Friday night, Aug. 14. Investigators learned the group was preparing to stage a takeover somewhere in Suffolk County, an area covering roughly 1,000 square miles across the eastern two-thirds of Long Island. Police tracked the group as it moved between several locations throughout the night, authorities said. VIRAL TEEN TAKEOVERS UNLEASH CHAOS NATIONWIDE AS MALLS, BEACHES AND RESTAURANTS BECOME BATTLEGROUNDS Officers first broke up attempted gatherings near Commack Road and Sunrise Highway in Islip before disrupting another near Route 112 and Main Street in Patchogue. Police finally interc...